Which enzyme facilitates the conversion of malate back to oxaloacetate?

Which enzyme facilitates the conversion of malate back to oxaloacetate?

• A. Alpha-ketoglutarate dehydrogenase
• B. Malate dehydrogenase
• C. Citrate synthase
• D. Fumarase

Answer: (B)

The enzyme that facilitates the conversion of malate back to oxaloacetate is malate dehydrogenase. This enzyme plays a crucial role in the citric acid cycle by catalyzing the reversible oxidation of malate to oxaloacetate, utilizing NAD+ as a cofactor, which is then reduced to NADH in the process. This reaction is important because it regenerates oxaloacetate, allowing the cycle to continue and facilitating the subsequent condensation with acetyl-CoA to form citrate. The activity of malate dehydrogenase is vital for maintaining the flow of metabolites within the cycle and impacts overall cellular respiration efficiency.

The enzyme that facilitates the conversion of malate back to oxaloacetate is malate dehydrogenase. This enzyme plays a crucial role in the citric acid cycle by catalyzing the reversible oxidation of malate to oxaloacetate, utilizing NAD+ as a cofactor, which is then reduced to NADH in the process. This reaction is important because it regenerates oxaloacetate, allowing the cycle to continue and facilitating the subsequent condensation with acetyl-CoA to form citrate. The activity of malate dehydrogenase is vital for maintaining the flow of metabolites within the cycle and impacts overall cellular respiration efficiency.